MEXICO CITY — Security, sovereignty, tariffs, trade, drugs and migration — all hot-button issues for the Trump administration and its neighbors in the Western Hemisphere — will top Secretary of State Marco Rubio’s agenda this week on his third trip to Latin America since becoming chief US diplomat.

The visit comes as the Trump administration has dramatically stepped up operations against drug cartels in the Caribbean, including recent military deployments and what it said was a lethal strike on a suspected drug-carrying vessel.

In talks with leaders in Mexico and Ecuador on Wednesday and Thursday, Rubio will make the case that broader, deeper cooperation with the US on those issues is vitally important to improving health, safety and security in the Americas and the Caribbean.

Yet, President Donald Trump has alienated many in the region — far beyond the usual array of US antagonists like Cuba, Nicaragua and Venezuela — with persistent demands, coupled with threats of sweeping tariffs and massive sanctions for not complying with his desires.

Shortly before Rubio left for Mexico, he and Trump announced the US military had carried out a strike in the southern Caribbean against a vessel hauling drugs that departed from Venezuela.

Trump announced that the vessel was being operated by the Tren de Aragua gang, which his administration has designated a foreign terrorist organization, and that 11 people were killed in the strike, which he said took place in international waters.

“Please let this serve as notice to anybody even thinking about bringing drugs into the United States of America. BEWARE!” Trump said.

Tariffs, migration and cartels will top Rubio's talks in Mexico and Ecuador this week

Rubio, speaking to reporters before boarding his plane to Mexico, said Trump “is going to be on offense against drug cartels and drug trafficking in the United States.

“It destabilizes not just the country but the entire Caribbean basin.”

Meanwhile, Trump has demanded, and so far won, some concessions from Mexican President Claudia Sheinbaum’s government, which is eager to defuse his tariff threats., This news data comes from:http://www.gyglfs.com

Rubio arrived in Mexico City just a few hours after Sheinbaum had planned to lead a meeting of the country’s most important security forum, which brings together all 32 governors, the army, navy, federal prosecutor’s office and security commanders to coordinate actions across Mexico.

Sheinbaum had been talking for weeks about how Mexico was finalizing a comprehensive security agreement with the State Department that, among other things, was supposed to include plans for a “joint investigation group” to combat the flow of fentanyl and the drug’s precursors into the US and weapons from north to south.

“Under no circumstance will we accept interventions, interference or any other act from abroad that is detrimental to the integrity, independence and sovereignty of the country,” she said Monday in her State of the Nation Address marking her first year in office.

Tariffs, migration and cartels will top Rubio's talks in Mexico and Ecuador this week

Sheinbaum lowered her expectations Tuesday, saying it would not be a formal agreement but rather a kind of memorandum of understanding to share information and intelligence on drug trafficking or money laundering obtained “by them in their territory, by us in our territory, unless commonly agreed upon.”

“There will be moments of greater tension, of less tension, of issues that we do not agree on, but we have to try to have a good relationship, and I believe tomorrow’s meeting will show that,” Sheinbaum said of her meeting Wednesday with Rubio.